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Cardiology
Research
Morgan Stanley Children's Hospital of NewYork-Presbyterian is internationally renowned for its ongoing clinical and basic research to advance the understanding and treatment of cardiovascular disease in children and adolescents.
The Hospital has a very active pediatric cardiology research program with general ongoing clinical studies involving electrophysiology, echocardiology, fetal echocardiography and exercise. The program was one of seven institutions that received a highly competitive National Heart, Lung and Blood Institute (NHLBI) grant for multicenter research.
Some of the current clinical research projects include:
- investigation of congenital heart disease and how it is influenced by surgical and catheterization interventions;
- Federal Drug Administration (FDA)-approved investigations of new interventional cardiology devices;
- multicenter clinical trials for drug therapy for primary pulmonary hypertension;
- airway and vascular reactivity in pulmonary vascular disease -a collaborative study with Critical Care and General Surgery;
- cross-sectional study of outcome after the Fontan operation for single ventricle;
- effect of corticosteroid administration on the outcome of acute Kawasaki disease, the most common form of vasculitis in children;
- a study - in collaboration with the Pediatric Cardiac Surgical Service - of alternate methods to repair Hypoplastic Left Heart Syndrome in the neonatal period.
Basic research is looking at:
- the role of angiotensin (family of peptides that act as vasoconstrictors to narrow blood vessels) in the restructuring of postnatal cardiac muscle cells and ventricular growth;
- the role of statins in regulating apoptosis (form of cell death) and angiogenesis (development of new blood vessels) in heart failure;
- genetic research in hypertrophic cardiomyopathy.
As a member of a national cooperative study, the Pediatric Cardiology Division has also published a number of papers relating to the effects of the HIV virus on the hearts of infants and children.
The Pulmonary Hypertension Center at Morgan Stanley Children's Hospital participates in numerous multicenter clinical trials for drug therapy for primary pulmonary hypertension. The Center receives significant support from the National Institutes of Health for its scientific and clinical work.
Morgan Stanley Children's Hospital is also studying the effectiveness of the drug Amlopidine for treating hypertension and another drug for treating diseases of the heart muscle.
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