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Critical Care

Research

Research in the Division of Pediatric Critical Care Medicine is comprised of both basic science and clinical research components. The basic science research component, directed by Dr. Susan Vannucci, focuses on experimental models of injury to the developing brain and heart, such as hypoxia-ischemia, hypoglycemia, and cardiac arrest and CPR. Current studies are investigating neuro- and cardio-protective intervention strategies that can be translated into clinical practice within the PICU/CICU.

The division also has a number of clinical research studies underway. Dr. Marilyn Morris is studying mechanisms to address informed consent for emergency clinical trials. She has developed a mechanism to conduct these trials in a way that is acceptable to parents of critically ill children and complies with federal regulations for research with a waiver of informed consent. Dr. George Hardart's research focuses on theoretical and empirical research in medical decision-making and the role of the family in that decision-making process.

Other major clinical research themes of the division include clinical studies on:

  • cerebral and cardiopulmonary resuscitation including the use of hypothermia
  • use of renal replacement therapies in the management of fluid balance and inflammatory states
  • use of amiodarone in resuscitation
  • use of vasopressin in shock states, sepsis models and the inflammatory cascade
  • neurologic monitoring after single ventricle surgery
  • central line sepsis

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